Table 4.

Univariate and multivariate cox regression analysis of disease-free survival

Clinical variations	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.00 (0.99–1.02)	0.678
Sex
Male	Ref
Female	0.99 (0.76- 1.30)	0.969
BMI	0.95 (0.91–0.99)	0.033	0.94 (0.90–0.98)	0.008
CA199 (U/mL)
< 150	Ref
≥ 150, < 300	1.06 (0.72–1.55)	0.774	1.06 (0.72–1.56)	0.759
≥ 300	1.49 (1.12–1.99)	0.006	1.52 (1.14–2.03)	0.005
Operative time	1.00 (1.00–1.00)	0.044	1.0008(0.999–1.003)	0.463
Estimated blood loss	1.00 (1.00–1.00)	0.005	1.00 (1.00–1.01)	0.008
Tumor size	1.19 (1.06–1.33)	0.003	1.06 (0.91–1.23)	0.472
PV/SMV reconstruction
No	Ref
Yes	1.25 (0.81–1.93)	0.312
T stage
T1	Ref
T2	1.3455 (0.94–1.93)	0.106	1.26 (0.87–1.81)	0.221
T3	1.93 (1.34–2.80)	< 0.001	1.82 (1.25–2.66)	0.002
N stage
N0	Ref
N1	0.98 (0.74–1.30)	0.902
N2	1.10 (0.69–1.76)	0.688
Nodal status
N−	Ref
N+	1.00 (0.77–1.30)	0.971
Examined lymph node
≤ 8	Ref
> 8	1.13 (0.87–1.48)	0.356
LNR
< 0.1	Ref
≥ 0.1	1.05 (0.78–1.40)	0.754
Differentiation
Well-intermediate	Ref
Poor	1.13 (0.84–1.53)	0.425
Margin
R0	Ref
R1	1.40 (0.94–2.08)	0.097	1.27 (0.85–1.90)	0.246
LVI
Negative	Ref
Positive	1.19 (0.92–1.54)	0.190
PNI
Negative	Ref
Positive	0.96 (0.72–1.29)	0.789
Adjuvant chemotherapy
No	Ref
Yes	1.08 (0.84–1.40)	0.538
Surgery
OPD	Ref
RPD	0.88 (0.67–1.16)	0.359	0.90 (0.68–1.19)	0.456

Univariable associations (P < 0.10) that were selected for multivariable analysis and significant factors (P < 0.05) on multivariable analysis are shown in bold