Table 5.
Univariate and multivariate cox regression analysis of overall survival
| Clinical variations | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | 1.00 (0.99–1.02) | 0.824 | ||
| Sex | ||||
| Male | Ref | |||
| Female | 0.94 (0.70–1.26) | 0.680 | ||
| BMI | 0.95 (0.91–1.00) | 0.057 | 0.94 (0.89–0.99) | 0.012 |
| CA199 (U/mL) | ||||
| <150 | Ref | |||
| ≥ 150, < 300 | 1.03 (0.67–1.56) | 0.907 | 1.06 (0.70–1.61) | 0.785 |
| ≥ 300 | 1.48 (1.09–2.01) | 0.013 | 1.56 (1.15–2.13) | 0.005 |
| Operative time | 1.00 (1.00–1.00) | 0.114 | ||
| Estimated blood loss | 1.00 (1.00–1.00) | 0.006 | 1.00 (1.00–1.00) | 0.008 |
| Tumor size | 1.17 (1.03–1.32) | 0.015 | 1.08 (0.92–1.25) | 0.355 |
| PV/SMV reconstruction | ||||
| No | Ref | |||
| Yes | 1.36 (0.84–2.19) | 0.208 | ||
| T stage | ||||
| T1 | Ref | |||
| T2 | 1.14 (0.77–1.67) | 0.510 | 1.14 (0.77–1.68) | 0.514 |
| T3 | 1.79 (1.21–2.64) | 0.003 | 1.71 (1.15–2.54) | 0.008 |
| N stage | ||||
| N0 | Ref | |||
| N1 | 1.09 (0.81–1.48) | 0.559 | ||
| N2 | 0.98 (0.58–1.66) | 0.951 | ||
| Nodal status | ||||
| N− | Ref | |||
| N+ | 1.07 (0.81–1.42) | 0.634 | ||
| Examined lymph node | ||||
| ≤ 8 | Ref | |||
| > 8 | 1.21 (0.90–1.63) | 0.201 | ||
| LNR | ||||
| < 0.1 | Ref | |||
| ≥ 0.1 | 1.07 (0.78–1.46) | 0.687 | ||
| Differentiation | ||||
| Well-intermediate | Ref | |||
| Poor | 0.96 (0.69–1.32) | 0.786 | ||
| Margin | ||||
| R0 | Ref | |||
| R1 | 1.24 (0.80–1.91) | 0.341 | ||
| LVI | ||||
| Negative | Ref | |||
| Positive | 1.35 (1.01–1.79) | 0.040 | 1.45 (1.09–1.95) | 0.012 |
| PNI | ||||
| Negative | Ref | |||
| Positive | 1.01 (0.73–1.39) | 0.953 | ||
| Adjuvant chemotherapy | ||||
| No | Ref | |||
| Yes | 1.05 (0.79–1.38) | 0.743 | ||
| Surgery | ||||
| OPD | Ref | |||
| RPD | 0.77(0.57–1.04) | 0.094 | 0.77(0.57–1.05) | 0.094 |
Univariable associations (P < 0.10) that were selected for multivariable analysis and significant factors (P < 0.05) on multivariable analysis are shown in bold