Table 2.

Primary and secondary outcomes (adjusted for stratification variables)

Outcome	Restrictive fluid management (n = 49)	Usual care (n = 51)	Restrictive fluid management vs usual care (95% CI)a	P valueb
Cumulative fluid balance at 72 h from randomization, mean (SD) mLc	− 1080 (2003)	61 (3131)	− 1148 (− 2200; − 97)	0.033
Duration of AKI (days), median [IQR]d	2 [1–3]	3 [2–7]	− 1 (− 3; 0)	0.071
Number of patients-receiving RRT, n (%)e	6/46 (13)	15/50 (30)	0.42 (0.16; 0.91)	0.043
Cumulative fluid balance at 24 h from randomization, mean (SD) mLc	− 416 (1194)	409 (1566)	− 822 ( − 1381; − 264)	0.004
Cumulative fluid balance at ICU discharge/day 7, mean (SD) mLc	− 2166 (2988)	− 650 (4469)	− 1532 (− 3036; − 29)	0.046
Cumulative dose of furosemide per day, median [IQR] mgf	0 (0–19)	1.4 (0–26.2)	0 (− 11; 5.7)	0.700

AKI acute kidney injury, RRT renal replacement therapy

^aAdjusted (severity of AKI and presence of fluid overload) difference in means/median or risk ratio with 95% CIs

^bP value derived from regression model adjusted for stratification variables (severity of AKI and presence of fluid accumulation)

^cThe last available value for cumulative balance was analyzed for all patients even if ICU discharge or consent withdrawal would have occurred before endpoint was fulfilled

^dTruncated at 7 days, ICU discharge, or consent withdrawal. Data missing for three patients-receiving restricted fluid management and one in usual care

^eTruncated at 14 days (RRT provided post-ICU discharge included)

^fPer oral furosemide dose divided by 2 to make it comparable to intravenous doses