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. 2020 Jul 6;25(2):587–596. doi: 10.1007/s11325-020-02086-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Multivariate mixed regression model on change in percent predicted of FEV₁ and FVC between visits, showing coefficients with 50% and 95% confidence intervals. Adjusted for pack-years, baseline spirometry value and centre. Subgraphs by doctor’s diagnosed asthma. Note that variables differ in scale (categorical, gender; ordinal, OSA symptom score; continuous, BMI, age), affecting the interpretation of each coefficient. OSA, obstructive sleep apnoea; f-u, follow-up; % pred, percent predicted