Table 4. FibroTest™ results.
Summary statistics are mean +/− SD for continuous variables and counts with percentages for categorical variables. Results are stratified by FibroTest™ score. To evaluate (univariate) association of each characteristic with FibroTest™ score, we used t-test to compare means of continuous variables and chi-square tests to compare proportions of categorical variables. Percentages have been rounded to the nearest whole number.
| Score Indicating F0 | Score Indicating >F0 | p value | |
|---|---|---|---|
| N (%) | 19 (68%) | 9 (32%) | |
| Baseline Information | |||
| Age (years) | 13.6 +/− 10.3 | 28.0 +/− 17.4 | 0.01 |
| Males (%) | 5 (26%) | 7 (78%) | 0.03 |
| History of HA | 12 (63%) | 4 (44%) | 0.60 |
| BMI Category | 0.78 | ||
| Healthy | 8 (42%) | 4 (44%) | |
| Overweight or Obese | 10 (53%) | 5 (56%) | |
| Underweight | 1 (5%) | 0 (0%) | |
| UCD Diagnosis | 0.41 | ||
| OTC deficiency | 7 (37%) | 3 (33%) | |
| ASS1 deficiency | 4 (21%) | 0 (0%) | |
| ASL deficiency | 5 (26%) | 3 (33%) | |
| ARG1 Deficiency | 3 (16%) | 3 (33%) | |
| Liver Biochemistries | |||
| ALT (units/L) | 36 +/− 26 | 51 +/− 23 | 0.14 |
| AST (units/L) | 41 +/− 20 | 40 +/− 15 | 0.92 |
| GGT (units/L) | 20 +/− 16 | 25 +/− 12 | 0.43 |
| Calculated Biomarkers | |||
| APRI | 0.37 +/− 0.21 | 0.41 +/− 0.19 | 0.59 |
| FIB-4 | 0.36 +/− 0.44 | 0.66 +/− 0.48 | 0.12 |
| ActiTest™ | 0.09 +/− 0.11 | 0.19 +/− 0.12 | 0.04 |
| Ultrasonography | |||
| Abnormal Hepatic Parenchyma | 5 (26%) | 8 (89%) | <0.01 |
| Liver Stiffness (m/s)1 | 1.41 (0.25) | 1.36 (0.14) | 0.63 |
Abbreviations: ALT, alanine aminotransferase; APRI, AST to platelet ratio; ARG1, arginase; ASL, argininosuccinate lyase; ASS1, argininosuccinate synthase; AST, aspartate aminotransferase; BMI, body-mass index; GGT, gamma glutamyltransferase; HA, hyperammonemia; N, number; OTC, ornithine transcarbamylase;
For liver stiffness, the values for one participant with IQR/median > 0.3 were not included in the analysis.