Table 5. ActiTest™.
Summary statistics are mean +/− SD for continuous variables and counts with percentages for categorical variables. Results are stratified by ActiTest™ score. To evaluate (univariate) association of each characteristic with ActiTest™ score, we used t-test to compare means of continuous variables and chi-square tests to compare proportions of categorical variables. Percentages have been rounded to the nearest whole number.
| Score Indicating A0 | Score Indicating >A0 | p value | |
|---|---|---|---|
| N (%) | 21 (75%) | 7 (25%) | |
| Baseline Information | |||
| Age (years) | 19.6 +/− 15.4 | 14 +/− 10.5 | 0.38 |
| Males (%) | 9 (43%) | 3 (43%) | 1.00 |
| History of HA | 11 (52%) | 5 (71%) | 0.66 |
| BMI Category | 0.84 | ||
| Healthy | 9 (43%) | 3 (43%) | |
| Overweight or Obese | 11 (52%) | 4 (57%) | |
| Underweight | 1 (5%) | 0 (0%) | |
| UCD Diagnosis | 0.04 | ||
| OTC Deficiency | 9 (43%) | 1 (14%) | |
| ASS1 Deficiency | 4 (19%) | 0 (0%) | |
| ASL Deficiency | 6 (29%) | 2 (29%) | |
| ARG1 Deficiency | 2 (10%) | 4 (57%) | |
| Liver Biochemistries | |||
| ALT (units/L) | 29 +/− 10 | 76 +/− 26 | <0.001 |
| AST (units/L) | 37 +/− 19 | 52 +/− 8 | 0.06 |
| GGT (units/L) | 19 +/− 10 | 30 +/− 24 | 0.07 |
| Calculated Biomarkers | |||
| APRI | 0.33 +/− 0.19 | 0.53 +/− 0.14 | 0.02 |
| FIB-4 | 0.48 +/− 0.49 | 0.40 +/− 0.43 | 0.70 |
| FibroTest™ | 0.15 +/− 0.11 | 0.26 +/− 0.19 | 0.06 |
| Ultrasonography | |||
| Abnormal Hepatic Parenchyma | 10 (48%) | 3 (43%) | 1.00 |
| Liver Stiffness (m/s)1 | 1.43 (0.24) | 1.29 (0.14) | 0.16 |
Abbreviations: ALT, alanine aminotransferase; APRI, AST to platelet ratio; ARG1, arginase; ASL, argininosuccinate lyase; ASS1, argininosuccinate synthase; AST, aspartate aminotransferase; BMI, body-mass index; GGT, gamma glutamyltransferase; HA, hyperammonemia; N, number; OTC, ornithine transcarbamylase;
For liver stiffness, the values for one participant with IQR/median > 0.3 were not included in the analysis.