Figure 3. Comparison of glutamatergic cell types in isocortex and hippocampal formation.

(A) Correspondence of HPF clusters to CTX subclasses, represented as a proportion of total matches. Lower panel shows the number of differentially expressed genes between each HPF cluster and its best-matched CTX cluster.

(B) Overview of glutamatergic cell types across all regions in CTX and HPF. Cell types are shown by supertypes and clusters within each supertype. CTX and HPF are separated by a solid line. Cell types in each CTX and RHP region (but not HIP) are displayed according to their layer specificity from top down. Cell types from RHP regions are aligned with those from CTX based on their similarity in layer specificity. IT types are shaded with pinkish ovals, PT, NP, CT and L6b types with yellowish ovals, and HIP types with blueish ovals. Each oval spans the major region(s) cells in each supertype come from. Within CTX, most supertypes span all areas. Some clusters within a given supertype exhibit preference for one or a few areas, and these clusters are shown as smaller ovals contained within the larger supertype oval. Cell types with similar projection patterns (intratelecephalic, extratelencephalic/subcerebral, or corticothalamic) are grouped by large brackets.

See also Figures S2–S3.