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. Author manuscript; available in PMC: 2021 Jun 12.
Published in final edited form as: Curr Opin Pharmacol. 2021 May 5;58:76–82. doi: 10.1016/j.coph.2021.03.011

Table 1.

SynDIG and PRRT proteins.

Name Also known as Isoforms Functional effects
SynDIG1 C20orf39, DSPC2, IFITMD5, TMEM90B Isoform 1 (258 aa) Isoform X1 (267 aa) Isoform X2 (253 aa) Isoform X3 (232 aa) Isoform X4 (206 aa) Promotes synaptic targeting and AMPAR clustering
Capucin SynDIG1-like, DSPC1, IFITMD4, TMEM90A, SynDIG2 Isoform 1 (238 aa) Unknown
Tmem91 DSPC3, IFITMD6, SynDIG3 Isoform a (172 aa) Isoform b (139 aa) Isoform c (133 aa) Isoform d (127 aa) Isoform e (123 aa) Unknown
PRRT1 C6orf31, DSPD1, IFITMD7, NG5, SynDIG4 Isoform 1 (306 aa) Isoform 2 (225 aa) Isoform 3 (153 aa) Promotes AMPAR surface expression; Slows deactivation and desensitization kinetics
PRRT2 BFIC2, BFIS2, DSPB3, DYT10, EKD1, FICCA, ICCA, IFITMD1, PKC Isoform 1 (340 aa) Isoform 2 (394 aa) Isoform 3 (299 aa) Isoform X1 (394 aa) Isoform X2 (346 aa) Isoform X3 (340 aa) Regulates synaptic vesicle release