Table 3.
Odds Ratios and 95% Confidence Intervals for Birth Characteristics and Risk of Pediatric Thyroid Cancer in Cases and Controls Born in California, 1978–2011, Stratified by Ethnicity
White (n = 380 cases, 7141 controls) |
Hispanic (n = 480 cases, 10,985 controls) |
|||
---|---|---|---|---|
OR | [CI] | OR | [CI] | |
Sex | ||||
Female | 1.00 | 1.00 | ||
Male | 0.22 | [0.17–0.28] | 0.23 | [0.18–0.29] |
Birth weight (per 500 g) | 1.16 | [1.04–1.29] | 1.05 | [0.96–1.15] |
Gestational age (weeks) | ||||
22–36 | 1.21 | [0.80–1.85] | 1.26 | [0.92–1.73] |
37–41 | 1.00 | 1.00 | ||
42–44 | 0.85 | [0.59–1.22] | 0.83 | [0.58–1.17] |
Unknown | 0.92 | [0.59–1.45] | 1.07 | [0.73–1.57] |
Maternal age (years) | ||||
<20 | 0.86 | [0.45–1.64] | 0.61 | [0.42–0.90] |
20–24 | 1.04 | [0.74–1.45] | 0.90 | [0.69–1.16] |
25–29 | 1.00 | 1.00 | ||
30–34 | 0.83 | [0.62–1.12] | 0.87 | [0.64–1.16] |
≥35 | 0.92 | [0.62–1.36] | 0.75 | [0.55–1.12] |
Maternal education (years) | ||||
<12 | 0.70 | [0.37–1.31] | 0.82 | [0.62–1.08] |
12 | 1.00 | 1.00 | ||
13–15 | 1.18 | [0.82–1.71] | 1.58 | [1.15–2.16] |
16+ | 1.33 | [0.92–1.92] | 1.60 | [1.04–2.45] |
Unknown | 0.91 | [0.52–1.58] | 1.20 | [0.75–1.92] |
Mother's place of birth | ||||
United States | 1.00 | 1.00 | ||
Foreign | 1.25 | [0.90–1.73] | 1.05 | [0.86–1.29] |
Paternal age (years) | ||||
<25 | 0.66 | [0.42–1.04] | 1.07 | [0.77–1.49] |
25–29 | 0.92 | [0.68–1.25] | 1.06 | [0.80–1.41] |
30–34 | 1.00 | 1.00 | ||
35–39 | 1.09 | [0.79–1.51] | 1.29 | [0.91–1.83] |
≥40 | 1.10 | [0.73–1.66] | 1.09 | [0.69–1.73] |
Unknown | 0.75 | [0.37–1.51] | 0.78 | [0.47–1.29] |
Birth order | ||||
First | 1.00 | 1.00 | ||
Second | 1.00 | [0.78–1.29] | 0.80 | [0.63–1.02] |
Third+ | 0.95 | [0.70–1.29] | 0.73 | [0.56–0.96] |
Mode of delivery | ||||
Vaginal | 1.00 | 1.00 | ||
C-section | 1.14 | [0.86–1.51] | 0.89 | [0.67–1.17] |
Miscarriage/stillbirth | ||||
Never | 1.00 | 1.00 | ||
Ever | 1.17 | [0.90–1.51] | 1.02 | [0.79–1.33] |
Maternal pregnancy complication | ||||
Never | 1.00 | 1.00 | ||
Ever | 1.12 | [0.83–1.50] | 0.79 | [0.58–1.06] |
Unknown | 1.10 | [0.30–4.06] | 2.59 | [0.51–13.05] |
Previous C-section | ||||
Never | 1.00 | 1.00 | ||
Ever | 0.87 | [0.56–1.35] | 1.11 | [0.74–1.65] |
Unknown | 0.73 | [0.19–2.79] | 0.44 | [0.07–2.65] |
Regression models are multivariable models with all variables listed in table included.