Table 1.

Characteristics of patients with hemoglobin Mizuho—a systematic review.

Author	N	Sex	Country of origin	Year of birth	Hb F %/age at determination	Transfusion dependency	Transfusions frequency	Sx/timeline	Need of Transfusion post-Sx	Clinical follow-up	Bone marrow aspirate
Ohba et al. 1977	1	F	Japan	1971	6.8%/3 years	Yes	Monthly, start 18 months	Yes, at 4 years	No	NA	Erythroid hyperplasia
Labotka et al. 1990	2	F	Italy	1986	NA	Yes	Monthly, start 6 months	Yes, at 3 years	No	NA	Hypercellular erythroid hyperplasia
Keeling et al. 1991	3	M	America	1986	35%/2 years 22%/4 years	No	Unknown	Yes, at 4 years	No	NA	NA
Harthoorn et al. 1994	4	M	The Netherlands	1989	31%/16 months 16%/3 years 9.8%/5 years	Yes	Every 8 weeks, start 2 years	Yes, at 6 years	No	Papillary thyroid carcinoma, Gilbert’s syndrome; hepatic failure leading to liver transplant	Active erythropoiesis
Perera et al. 2015 Family (2 members)	5	F	Sri Lanka	1969	NA	Yes	NA	Yes, early age	Yes	NA	NA
	6	M	Sri Lanka	1996	NA	Yes	NA	Yes, early age	Yes	NA	NA
Njue et al. Family (3 members)	7	F	Switzerland	1979	1.8%/2 years	Yes	Approx. monthly, start at 2 months	Yes, at 3 years	Yes, RBC exchange every 6 weeks	Moyamoya disease	Erythroid hyperplasia
	8	F	Switzerland	2003	1.4%/4 years	Yes	Monthly, start 7 months	Yes, at 7 years	Every 6–10 months	None relevant	Not performed
	9	M	Switzerland	2009	N/A	Yes	Monthly, start 4 months	Yes, at 6 years	Every 3 months	None relevant	not performed