Cell cycle regulator	Target	Role	References
Cyclin D1-3, E1-2	Oct4, Sox2, Nanog	Maintenance of pluripotency	[64]
Cyclin D1-3	TGFb	Endoderm specification	[15]
Cyclin D1	Endo-, meso- and ectoderm genes	Endoderm specification Neuroectoderm differentiation	[65]
Cyclin E1-2		Extra-embryonic lineage specification	[67]
CDK1	OCT4	Trophectoderm specification	[71, 72]
	ERK signalling	Mesoendoderm specification	[70]
	Epigenetic writers, Dot1L	Endoderm specification	[74]
	TFCO2L1	Maintenance of pluripotency	[75]
CDK2	Oct4, Sox2, Nanog	Maintenance of pluripotency	[64]