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. 2020 Oct 7;44(7):1413–1423. doi: 10.1007/s40618-020-01439-7

Table 4.

Association between micronutrient deficiencies and increased CRP values in logistic regression models and at mediation analysis

Univariate regression Multivariate regressiona Indirect effects°
OR 95% CI p OR 95% CI p p
Iron deficiencyb 1.98 1.02–3.85 0.044 1.78 0.88–3.60 0.11 0.23
Vitamin B12 deficiencyc 5.46 1.22–24.5 0.026 5.84 1.25–27.2 0.024 0.94
Folate deficiencyd 4.06 1.94–8.47  < 0.001 4.02 1.87–8.66  < 0.001 0.45
 ≥ 2 nutritional deficiencies 2.62 1.42–4.82 0.002 2.31 1.21–4.42 0.010 0.12

aModel adjusted for age, sex, BMI, glycated hemoglobin. Each row is a model

bTransferrin saturation < 15% (females), < 20% (males)

cVitamin B12 < 200 pg/mL

dFolate < 3.0 ng/mL

°p values for the presence of indirect effects mediated by age, sex, BMI, glycated hemoglobin at mediation analysis