Table 4.

Statistical analysis of pharmacokinetic parameters of plasma atogepant and acetaminophen administered alone and when co-administered

	Pharmacokinetic parameters	Geometric LSM		GMR (test/reference)	90% lower CI	90% upper CI
		Test	Reference
Plasma atogepant Test = Atogepant + Acetaminophen Reference = Atogepant	Cmax (ng/mL)	717.17	717.19	1.00	0.90	1.11
	AUC0–t (ng·h/mL)	3794.44	3349.76	1.13	1.05	1.22
	AUC0–∞ (ng·h/mL)	3828.79	3395.58	1.13	1.04	1.22
Plasma acetaminophen Test = Atogepant + Acetaminophen Reference = Acetaminophen	Cmax (µg/mL)	13.27	14.96	0.89	0.81	0.97
	AUC0–t (µg·h/mL)	54.13	57.88	0.94	0.89	0.99
	AUC0–∞ (µg·h/mL)	55.61	59.29	0.94	0.89	0.99

AUC_0–t area under the plasma drug concentration-time curve (AUC) from time 0 to time t, AUC_0–∞ AUC from time 0 to infinity, C_max maximum plasma drug concentration, GMR geometric means ratio, LSM least squares mean