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. 2021 Jun 11;12(6):606. doi: 10.1038/s41419-021-03896-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Circulating cf-DNA and Cit H3-DNA complexes in abdominal sepsis patients (n = 5) and healthy controls (n = 5) were analyzed by ELISA. B Serum I-FABP and D-lactate were analyzed by ELISA. C Correlation between circulating NETs biomarkers (cf-DNA and Cit H3-DNA complex) and circulating intestinal injury biomarkers (I-FABP and D-lactate). NETs neutrophil extracellular traps, cf-DNA cell-free DNA, Cit H3 citrullinated histone 3, ELISA enzyme-linked immunosorbent assay, I-FABP intestinal fatty-acid binding protein. Data are expressed as the means ± SD. *P < 0.05; **P < 0.01.