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Summary of affinity and thermodynamic binding parameters for PALS1 PDZ domain interactions with SARS CoV-1 and -2 PBM peptides.
| KD (μM) | ΔH (kcal/mol) | ΔG (kcal/mol) | −TΔS (kcal/mol/K) | N | |
|---|---|---|---|---|---|
| SARS-CoV-1 PBM | 29.6 ± 2.3 | −0.67 ± 0.01 | −6.15 ± 0.03 | 5.49 ± 0.04 | 1.0 ± 0.02 |
| SARS-CoV-2 PBM | 22.8 ± 1.2 | −0.68 ± 0.01 | −6.34 ± 0.02 | 5.66 ± 0.15 | 0.8 ± 0.1 |
| MERS-CoV PBM | NB | NB | NB | NB | NB |
NB denotes no binding. Each of the value was calculated from at least three independent experiments. Errors are ±SD.
