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. 2021 Jun 11;12:3555. doi: 10.1038/s41467-021-23746-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — This figure shows the longitudinal PACC trajectory expected for a biomarker-negative or biomarker-positive CU individual with average age, average education, and female sex. β-coefficients at the top left of each panel are presented in terms of “points/year per standard deviation change in biomarker value” and are derived from linear mixed effects models with longitudinal PACC as outcome and age, sex, education, plus each plasma biomarker included separately from each other as predictors. All statistical tests were two-sided with no adjustment for multiple comparisons. Shaded areas represent 95% confidence intervals of the regression lines.