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. 2021 Jun 11;12:3555. doi: 10.1038/s41467-021-23746-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — This figure shows the reduction in sample size resulting from using plasma biomarkers for inclusion enrichment in theoretical clinical trials aimed at slowing decline in PACC or reducing risk of AD dementia in a CU population. Sample sizes were estimated for a trial enriched using pre-defined cutoffs for each biomarker as inclusion threshold. Confidence intervals were derived by calculating the 0.025% and 95.75% percentile values from 1000 bootstrapped trials over n = 435 individuals. Source data is available in Supplementary Table 8.