Table 3.
Results of Cox regression analysis of factors associated with BCR-free survival.
| Univariate | Multivariatea | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P-value | HR (95% CI) | P-value |
| PCa-MRS | ||||
| High vs low score | 4.23 (2.58–6.96) | 1.25 × 10−8 | 2.26 (1.29–3.96) | 0.004 |
| Age | 1.02 (0.98–1.06) | 0.305 | ||
| BMI | 1.05 (0.97–1.15) | 0.246 | ||
| Prostate volume | 1.00 (0.99–1.02) | 0.736 | ||
| Preoperative PSA | 1.02 (1.01–1.03) | 2.49 × 10−8 | 1.01 (1.00–1.02) | 0.014 |
| PSA density | 1.75 (1.40–2.19) | 7.59 × 10−7 | ||
| Clinical Gleason score | 4.43 × 10−6 | 1.74 × 10−4 | ||
| 7(3 + 4) vs ≤6 | 7.58 (1.47–39.1) | 0.015 | 7.29 (1.41–37.7) | 0.018 |
| 7(4 + 3) vs ≤6 | 16.9 (3.96–72.1) | 1.34 × 10−4 | 12.6 (2.92–54.2) | 0.001 |
| ≥8 vs ≤6 | 28.8 (6.90–120.1) | 3.99 × 10−6 | 20.4 (4.80–86.4) | 4.33 × 10−5 |
aMultivariate analysis was performed by Cox regression analysis with backward selection using PCa-MRS (categorical), preoperative PSA, and clinical Gleason score (categorical). To avoid the collinearity effect, PSA density was excluded from the multivariate analysis.