Table 4.
Relationship between DNA methylation and gene expression as reported in the IMETHYL database.
| CpG ID | Nearest genea | Gene featurea | Methylation level b | Methylation averageb% (SD) | FPKMb,c average(SD) |
|---|---|---|---|---|---|
| cg14653250 | PC | TSS200 | Low | 0.77 (1.51) | 0.61 (0.18) |
| cg02338947 | FAM124B | 3′UTR | High | 84.10 (24.48) | −0.42 (0.18) |
| cg01573121 | DNAJC28 | 5′UTR | High | 86.66 (8.10) | −0.59 (0.15) |
| cg12144754 | PRPS1L1 | 1stExon | High | 97.81 (2.43) | Data not available |
| cg26859186 | PTPRN2 | Body | High | 96.10 (3.50) | 0.27 (0.17) |
| cg19712490 | CD81 | TSS200 | Low | 0.43 (1.48) | −0.61 (0.17) |
| cg12842013 | HOMEZ | 1stExon | Low | 0.39 (1.22) | 0.80 (0.09) |
| cg01099220 | LRRC14 | 3′UTR | Low | 2.09 (2.70) | 1.25 (0.07) |
| cg25806492 | SRRM1 | Body | Low | 2.55 (2.28) | 1.87 (0.07) |
| cg13767940 | BTG4 | TSS200 | Low | 6.40 (4.93) | Data not available |
| cg21010178 | PADI1 | TSS1500 | High | 94.17 (5.16) | Data not avaialable |
| cg22602019 | FAM167B | 3′UTR | Low | 13.63 (0.42) | −0.26 (0.17) |
| cg13198133 | Intergenic | Intergenic | High | 91.00 (5.71) | Data not vailable |
| cg02150674 | PHYH | TSS200 | Low | 0.71 (1.92) | 0.73 (0.10) |
aAnnotation were perfomed via IlluminaHumanMethylation450kanno.ilmn12.hg19. Homo sapiens (human) genome assembly GRCh37 (hg19)61.
bMethylation level according to iMETHYL database (low, medium, high). IMETHYL provides whole-DNA methylation (~24 million autosomal CpG sites), whole-genome (~9 million single-nucleotide variants) and whole-transcriptome (>14 000 genes) data for CD4+ T-lymphocytes, monocytes and neutrophils collected from ~100 subjects.
cFPKM Fragments Per Kilobase of transcript per Million mapped reads.