Prognostic impact of minimal residual disease (MRD) levels at the end of induction (EOI), as shown by Kaplan-Meier estimates of disease-free survival (DFS), for all patients (A), patients treated with protocol IB (B), and patients treated with araC, daunorubicin, etoposide (ADE)/mitoxantrone, araC, etoposide (MAE) (C). Outcome by treatment given of patients according to MRD at EOI, negative (D), intermediate (E), and high (F). Neg, MRD-negative; Interm, MRD-intermediate (< 5 × 10−4); High, MRD-high (≥ 5 × 10−4). CR1, first complete remission.