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. 2021 Jun 12;5(7):e598. doi: 10.1097/HS9.0000000000000598

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Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — CYCLON subcellular localization define prognosis subgroups in DLBCL patients. (A), IHC analysis of CYCLON revealing distinct expression patterns in DLBCL patients as indicated. (B), Kaplan-Meier analyses of PFS (left) and SOS (right) associated to CYCLON patterns. P values are derived from a log-rank test. PFS, extranucleolar: 18.52% (95% CI, 3.98–41.4); nucleolar: 61.11% (95% CI, 25.46–83.75); diffuse: 56.91% (95% CI, 30.7–76.4); negative: 60% (95% CI, 12.57–88.18); SOS: extranucleolar: 31.11% (95% CI, 11.36–53.43); nucleolar: 48.89% (95% CI, 8.8–81); diffuse: 74.85% (95% CI, 60–84.75); negative: 80% (95% CI, 20.38–96.92). (C), Multivariate bootstrap Cox regression analyses of CYCLON extranucleolar staining status (+/−), R-IPI (high/low), and Hans’ classification (GC/non-GC) for PFS and SOS. *Normal-approximation 95% CI based on bootstrap resampling (1000 replicates). Schoenfeld residual test, PFS model: global P = 0.58 and SOS model: global P = 0.72; Harrell’s C statistic, PFS model: C = 0.72 and SOS model: C = 0.77. CI = confidence interval; DLBCL = diffuse large B-cell lymphoma; GC = germinal center; Hans = Hans algorithm defining non-GC and GC DLBCL subtypes; HR = hazard ratio; IHC = immunohistochemical; PFS = progression-free survival; R-IPI = revised version of the International Prognostic Index; SOS = specific overall survival.