TABLE 3.
Univariate and multivariable analysis of markers and clinical characteristics
| Parametera | Univariate logistic regressionb | Multivariable logistic regression | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Recipient gender (M) | 0.28 (0.14–0.57) | <0.001* | — | |
| Recipient age at Tx | 0.96 (0.93–0.98) | 0.001* | 0.94 (0.89–0.99) | 0.014 |
| Donor age | 0.97 (0.95–0.99) | 0.037 | ||
| Donor type (deceased) | 2.05 (1.02–4.13) | 0.044 | ||
| hPRA (>5%) | 11.12 (2.56–48.26) | 0.001* | — | |
| HLA-A and -B mismatches | ||||
| 1 | 0.82 (0.23–2.91) | 0.76 | ||
| 2 | 1.29 (0.42–4.01) | 0.66 | ||
| 3 | 0.87 (0.28–2.71) | 0.80 | ||
| 4 | 0.72 (0.20–2.58) | 0.61 | ||
| HLA-DR mismatches | ||||
| 1 | 2.10 (0.91–4.83) | 0.083 | ||
| 2 | 0.93 (0.38–2.27) | 0.88 | ||
| DGF | 4.20 (1.54–11.44) | 0.005* | — | |
| Anti-IL2RA induction | 0.40 (0.13–1.24) | 0.11 | ||
| Primary transplantation | 0.12 (0.02–0.89) | 0.038 | ||
| miR-21-5p | 7.02 (3.16–15.60) | <0.001* | — | |
| miR-25-3p | 29.34 (8.60–100.09) | <0.001* | — | |
| miR-126-3p | 4.58 (2.43–8.63) | <0.001* | — | |
| miR-155-5p | 9.91 (4.41–22.26) | <0.001* | 4.36 (1.18–16.18) | 0.028 |
| miR-615-3p | 0.28 (0.14–0.57) | <0.001* | 0.12 (0.03–0.47) | 0.002 |
| CXCL-9 | 10.91 (4.78–24.91) | <0.001* | 6.72 (2.21–20.45) | 0.001 |
| CXCL-10 | 4.14 (2.32–7.38) | <0.001 | NA | |
| Days post-Tx | ||||
| 181–730 | 0.41 (0.19–0.88) | 0.378 | ||
| >730 | 0.28 (0.12–0.69) | 0.005 | ||
aThe following group sizes (rejection/no-rejection) applied to the logistic regression tests; for the miRs: 98/54, for CXCL-9: 108/43, and for the combined models: 92/41.
bTo prevent overfitting the multivariable model, a maximum of 10 of the most significant parameters from univariate (marked with *) were entered in the model. CXCL-10 was not included since it highly correlates with CXCL-9.
CI, confidence interval; DGF, delayed graft function; F, female; hPRA, historical PRA; M, male; miR, microRNA; OR, odds ratio; Tx, transplantation.