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. 2021 Jun 11;12:3579. doi: 10.1038/s41467-021-23681-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The PET-CT tomography of patient P07 at different diagnostic time points. B The alignment of all mutations in the primary and three relapse tumor samples from P07. The mutation numbers included in the analysis are shown in parentheses. C A phylogenetic tree showing evolutionary relationships between the tumor samples. Selected mutations are shown along the lineages. D A phylogenetic tree among the four tumor samples from P07 based on their LOH patterns.