Table 2.
Assessment of patient’s quality of life measured by PDQ-39 (n = 57).
| Dimension | M0 | M3 | M6 | M12 | M24 | Friedman test p value | Relative change M0–M24 |
|---|---|---|---|---|---|---|---|
| Physical score | 53.5 (18.1) | 51.3 (18.3) | 51.9 (17.6) | 48.9 (17.5)a | 54.1 (17.0) | 0.013 | +1.2% |
| Mobility | 57.7 (22.7) | 56.0 (22.5) | 56.2 (20.6) | 52.7 (19.9)a | 57.6 (18.8) | 0.036 | −0.09% |
| ADL | 49.9 (20.3) | 45.2 (20.0) | 47.0 (20.6) | 44.0 (20.4) | 49.3 (22.7) | 0.134 | −1% |
| Bodily discomfort | 46.9 (20.6) | 45.7 (19.7) | 47.1 (21.2) | 46.4 (20.1) | 52.1 (19.6) | 0.297 | +11% |
| Psychological score | 32.8 (11.5) | 32.0 (13.4) | 34.3 (12.6) | 33.3 (13.6) | 35.6 (12.4) | 0.366 | +8% |
| EMO | 41.7 (19.0) | 40.1 (17.6) | 38.3 (16.2) | 39.0 (17.5) | 41.2 (15.8) | 0.871 | −1.4% |
| Stigma | 35.0 (20.3) | 28.0 (21.9)a | 32.6 (25.8) | 34.1 (23.1)a | 30.8 (22.9)a | 0.027 | −11.8% |
| Social support | 16.2 (17.8) | 17.3 (21.2) | 23.1 (23.7) | 21.5 (21.6) | 25.3 (21.9)a | 0.015 | +55.8% |
| Cognition | 28.8 (17.7) | 34.2 (22.0) | 34.8 (17.8) | 33.5 (18.3) | 36.4 (18.4) | 0.387 | +26% |
| Communication | 34.1 (19.5) | 33.8 (22.2) | 38.0 (22.2) | 33.9 (19.2) | 40.8 (19.6)a | 0.018 | +19.6% |
| PDQ-39 total | 42.3 (12.3) | 40.8 (13.7) | 42.9 (14.8) | 40.3 (14.0) | 44.3 (13.4) | 0.054 | +4.6% |
Changes for each dimension, physical or psychological subscores, and PDQ-39 total score. Data are mean (SD). The PDQ-39 range is 0–100; the higher the score, the worse the self-reported quality of life; negative change = improvement. Missing values in PDQ-39 domain scores were imputed using the nearest available observations. Related samples Friedman’s two-way analysis of variance by ranks test followed by Wilcoxon tests with a Bonferroni Correction applied.
PDQ-39 39-item Parkinson’s disease questionnaire, AD activities of daily living, EMO emotional well-being.
ap value < 0.05 compared to M0. Since there was a strong trend toward significance for PDQ-39 total (p = 0.054), we checked the score evolution compared to M0 by paired comparisons and found that all the p values were >0.23; relative change = (mean Testfollow-up − mean Testbaseline)/Testbaseline × 100.