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. 2021 Jun 11;7:76. doi: 10.1038/s41523-021-00279-9

Fig. 2. Case-control frequencies of rare LoF (MAF < 0.005) and MS (MAF < 0.001) variants in known or proposed HBOC genes (N = 14).

Fig. 2

*Part of the data have been published previously in J. Clin. Oncol. 34(13), 1455–1459, Genet. Med. 21(4), 913–922, J. Pathol. 245(1), 53–60, J. Natl Cancer Inst. 111(12), 1332–1338, Nat. Genet. 50(10), 1346–1348 and Breast Cancer Res. Treat. 159(2), 385–392. Known pathogenic MS variants in ATM (c.7271 T > G) and TP53 (c.524 G > A, c.712 T > C, c.725 G > A, c.733 G > A, c.742 C > T and c.1009 C > T) were classified as LoF variants in this analysis.