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. 2021 Jun 11;11:12354. doi: 10.1038/s41598-021-91793-0

Figure 2.

Figure 2

Balance between neutralizing and enhancing activities against four prototype viruses. The NAb/EAb-balance assay was performed with a combination of serum (D1-14: A–D, D2-44: E–H, D2-57: I–L, D3-46: M–P, D4-12: Q–T and D4-49: U–X) and four prototype viruses (DENV-1: Mochizuki strain; DENV-2: NGC strain; DENV-3: H87 strain; and DENV-4: H241 strain). The blue, green, yellow and red triangles, corresponding to Fig. 1A, indicate the hours after fever onset. The abscissa indicates the serum dilutions and the ordinate shows the numbers of infected cells (both expressed as log10). Each data point represents the average of two separate assays; error bars indicate the SDs. Dotted lines indicate the mean numbers of infected cells plus or minus three times the SD (mean ± 3SD), to define neutralizing or enhancing activity, respectively.