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. 2021 May 28;9:656554. doi: 10.3389/fcell.2021.656554

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Copyright © 2021 Zhang, Li, Gao, Tong, Li, Wang, Du and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of 13 lncRNAs as candidate prognostic markers for ESCC. (A) Volcano plot exhibited differentially expressed lncRNAs. (B) Heatmap analysis showed that ESCC patients could be distinguished by dysregulated lncRNAs. (C) PCA showed successful segregation between tumor and normal tissues. (D) The intersection of differentially expressed and prognostic lncRNAs by DEseq2, log-rank, and cox analysis. (E–G) Exploratory KM analysis (log-rank test) of the OS probability (with 95% confidence intervals) in ESCC patients [(E) TNM stage; (F) lymph node metastasis; and (G) distant metastasis].