Figure 1.

Overview of the brain age prediction process. (A) Example of input modalities that were used in the brain age prediction process. (B) Main processing steps of the prediction method from reshaping image data into 2-dimensional matrixes with one row per subject that could be concatenated to contain all the considered modalities, through the k-fold prediction framework where dimension reduction and model training are performed on k-1 folds and resulting parameters are used in the prediction of age in the unseen fold. (C) Combined output from the prediction method and corresponding calculation of BAPG.