Figure 4.
Voxel-based vesicular acetylcholine transporter PET and total PIGD motor analysis. Significant clusters of the inverse correlation between total PIGD motor scores and regional VAChT PET binding as shown in t-scores superimposed on brain MRI atlas images. (false discovery rate-corrected P < 0.05). The most prominent findings localized to the bilateral metathalamus (medial and geniculate nuclei), bilateral proximal optic radiations, bilateral thalamus proper (esp. the lateral posterior nucleus of the thalamus), bilateral fimbriae, right more than left mesiotemporal lobes (including entorhinal cortex and hippocampus), bilateral caudate nuclei, cingulum, especially anterior and mid portions, right operculum and bilateral prefrontal, pericentral and insular cortices. Additional smaller foci are seen in the cerebellum, including the right superior and posterior vermis. PET imaging findings superimposed on International Consortium for Brain Mapping (ICBM) adopted Montreal Neurological Institute (MNI) MRI T1-weighted template.