Table 4.
Hyperfluorescent Areas, RPE Atrophy With and Without Outer Nuclear Layer Atrophy in GA, STGD, and Pattern Dystrophy
| A. | ||||
|---|---|---|---|---|
| RPE Atrophy | RPE Atrophy | |||
| With Outer | Without Outer | |||
| Channel | Nuclear Layer Atrophy | Nuclear Layer Atrophy | Unaffected Areas | P |
| SSC | 589 ± 178 ps | 431 ± 173 ps | 327 ± 79 ps | <0.001 |
| LSC | 687 ± 159 ps | 550 ± 160 ps | 417 ± 75 ps | <0.001 |
| B. | ||||
| Disease | Channel | Hyperfluorescent Areas | Atrophic Areas | P |
| GA (n = 32 eyes) | SSC | 388 ± 99 ps | 523 ± 178 ps | <0.001 |
| LSC | 507 ± 88 ps | 609 ± 130 ps | <0.001 | |
| STGD (n = 66 eyes) | SSC | 285 ± 81 ps | 301 ± 169 ps | 0.327 |
| LSC | 352 ± 81 ps | 385 ± 143 ps | <0.05 | |
| Pattern dystrophy (n = 18 eyes) | SSC | 295 ± 61 ps | 342 ± 191 ps | 0.271 |
| LSC | 338 ± 74 ps | 397 ± 145 ps | 0.117 | |
| Non-Atrophic, Normal | ||||
| Disease | Channel | Hyperfluorescent Areas | Fluorescent Areas | P |
| GA (n = 32 eyes) | SSC | 388 ± 99 ps | 322 ± 79 ps | <0.001 |
| LSC | 507 ± 88 ps | 421 ± 75 ps | <0.001 | |
| STGD (n = 66 eyes) | SSC | 285 ± 81 ps | 197 ± 70 ps | <0.001 |
| LSC | 352 ± 81 ps | 268 ± 89 ps | <0.001 | |
| Pattern dystrophy (n = 18 eyes) | SSC | 295 ± 61 ps | 233 ± 44 ps | <0.001 |
| LSC | 338 ± 74 ps | 283 ± 49 ps | <0.01 | |
Part A shows results from an analysis of variance among the different atrophic areas, specifically areas with RPE atrophy with and without outer nuclear layer atrophy, compared with unaffected areas. Part B shows Bonferroni-corrected P values of differences between hyperfluorescent areas and atrophic areas, as well as hyperfluorescent areas and unaffected areas. Both spectral channels (SSC, 498–560 nm; LSC, 560–720 nm) are shown.