Table 2.
Physical and conventional echocardiographic parameters in normal and Ang II-infused rats treated with vehicle or DAPA
| Parameters | CTL | CTL + DAPA | Ang II | Ang II + DAPA |
|---|---|---|---|---|
| BW (g) | 362.17 ± 12.67 | 358 ± 9.93 | 320.33 ± 15.31* | 318.5 ± 12.29* |
| SBP (mmHg) | 131.95 ± 13.49 | 134.4 ± 16.43 | 228.28 ± 14.62* | 222.67 ± 19.34* |
| DBP (mmHg) | 102.6 ± 16.62 | 106.77 ± 11.2 | 190.02 ± 18.49* | 173.1 ± 17.58* |
| HW (g) | 1.0 ± 0.08 | 1.03 ± 0.07 | 1.33 ± 0.05* | 1.14 ± 0.1*† |
| LVW (g) | 0.71 ± 0.07 | 0.71 ± 0.08 | 1.0 ± 0.03* | 0.85 ± 0.07*† |
| IVSd (mm) | 1.83 ± 0.08 | 1.82 ± 0.06 | 2.5 ± 0.14* | 1.85 ± 0.09† |
| LVEDd (mm) | 7.45 ± 0.65 | 7.49 ± 0.19 | 6.28 ± 0.42* | 7.06 ± 0.71† |
| LVEDs (mm) | 4.49 ± 0.26 | 4.37 ± 0.23 | 3.37 ± 0.23* | 4.0 ± 0.5*† |
| LVPWd (mm) | 1.68 ± 0.1 | 1.74 ± 0.13 | 2.32 ± 0.13* | 1.73 ± 0.12† |
| LVEDV (ml) | 0.94 ± 0.22 | 0.92 ± 0.05 | 0.58 ± 0.1* | 0.81 ± 0.24† |
| LVESV (ml) | 0.22 ± 0.04 | 0.2 ± 0.02 | 0.1 ± 0.02* | 0.17 ± 0.07*† |
| LVEF (%) | 75.47 ± 3.21 | 78.02 ± 2.57 | 82.88 ± 0.79* | 79.9 ± 1.99*† |
| LVFS (%) | 39.51 ± 2.83 | 40.61 ± 1.41 | 46.32 ± 0.85* | 43.46 ± 1.79*† |
| HR | 389.48 ± 21.59 | 377.53 ± 17.21 | 409.01 ± 26.04 | 409.32 ± 21.06 |
Values are presented as mean ± SD (n = 6 rats per group)
Data are expressed as the mean ± SD
BW body weight, SBP systolic blood pressure, DBP diastolic blood pressure, HW heart weight, LVW left ventricle weight, TL tibia length, IVSd end-diastole interventricular septum thickness, LVEDd left ventricular end-diastolic dimension, LVEDs left ventricular end-systolic dimension, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, LVPWd diastolic left ventricular posterior wall thickness, LVFS left ventricular fractional shortening, LVEF the left ventricular ejection fraction, HR heart rate
*P < 0.05 relative to CTL group
†P < 0.05 relative to Ang II group