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. 2021 Jun 12;17:161–169. doi: 10.1016/j.eng.2021.05.009

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© 2021 THE AUTHORS

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — Changes in the features of monocyte clusters. (a) UMAP of monocytes from patients with different disease severity levels and from controls. (b) UMAP of different groups. (c) Violin map of genes with high expression in Mono 0 and Mono 5 cells. (d) Enriched pathway of AREG and EREG in Mono 0 cells. (e) Enriched pathway of AREG and EREG in Mono 5 cells. CDKN1A: cyclin-dependent kinase inhibitor 1A gene; HBEGF: heparin-binding epidermal growth factor (EGF)-like growth factor gene; PIK3R: phosphoinositide-3-kinase regulatory gene; PAK: p21 protein (Cdc42/Rac)-activated kinase gene; NCK: NCK adaptor protein gene; ARAF: A-Raf proto-oncogene; ELK1: E26 transformation-specific transcription factor gene; GSK3B: glycogen synthase kinase 3 β gene; NRAS: neuroblastoma rat sarcoma viral (v-ras) oncogene homolog; ABL: ABL proto-oncogene; HRAS: Harvey rat sarcoma viral oncogene homolog; RAF1: Raf-1 proto-oncogene; MTOR: mechanistic target of rapamycin gene; MAPK: mitogen-activated protein kinase gene; STAT5B: signal transducer and activator of transcription 5B gene; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1 gene; NRG: neuregulin gene; CAMK2B: calcium/calmodulin-dependent protein kinase II β gene; BAD: BCL2-associated agonist of cell death gene; BTC: betacellulin gene; CBLC: Cbl proto-oncogene C; SHC (Src homology 2 domain containing) transforming protein gene; CAMK2A: calcium/calmodulin-dependent protein kinase II α gene; EGF: epidermal growth factor gene; GAB1: GRB2-associated binding protein 1 gene; RPS6KB2: ribosomal protein S6 kinase 70 kDa polypeptide 2 gene; PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α gene; BRAF: B-Raf proto-oncogene; MYC: v-myc avian myelocytomatosis viral oncogene homolog; TGFA: transforming growth factor α gene; AKT3: v-akt murine thymoma viral oncogene homolog 3; CBLB: Cbl proto-oncogene B; PIK3CB: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β gene; PTK2: protein tyrosine kinase 2 gene; PIK3CG: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ gene; SOS1: son of sevenless homolog 1 (Drosophila) gene; PIK3CD: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Δ gene; CAMK2D: calcium/calmodulin-dependent protein kinase II Δ gene; CRKL: v-crk avian sarcoma virus CT10 oncogene homolog-like; MAP2K7: mitogen-activated protein kinase 7 gene; KRAS: Kirsten rat sarcoma viral oncogene homolog.