Table 4.
Effects of different MTNR1B rs10830963 genotypes in T2DM patients on clinical traits determined before and after nateglinide treatment
| Parameters | CC(n = 26) | CG(n = 26) + GG(n = 8) | P value |
|---|---|---|---|
| N (male/female) | 26 (16/10) | 34(20/14) | 0.902Δ |
| FPG (mmol/L) | |||
| Before | 10.73 ± 2.05 | 10.81 ± 1.92 | 0.877 |
| After | 6.98 ± 1.35 | 7.94 ± 1.23 | 0.006* |
| DV | − 3.75 ± 1.68 | − 2.87 ± 1.32 | 0.027* |
| PPG (mmol/L) | |||
| Before | 14.51 ± 4.31 | 13.04 ± 4.72 | 0.220 |
| After | 9.34 ± 3.24 | 9.27 ± 3.49 | 0.937 |
| DV | − 5.17 ± 4.08 | − 3.77 ± 3.19 | 0.141# |
| FINS (mU/L) | |||
| Before | 8.82 ± 6.81 | 7.80 ± 4.20 | 0.478 |
| After | 10.18 ± 6.60 | 9.32 ± 3.64 | 0.522 |
| DV | 1.36 ± 4.10 | 1.84 ± 3.80 | 0.641 |
| PINS (mU/L) | |||
| Before | 31.42 ± 20.47 | 27.47 ± 16.43 | 0.410 |
| After | 48.41 ± 19.78 | 37.13 ± 20.87 | 0.038* |
| DV | 16.99 ± 17.82 | 9.66 ± 19.37 | 0.138 |
| HOMA-IR | |||
| Before | 4.48 ± 2.88 | 3.24 ± 1.73 | 0.066 |
| After | 3.39 ± 2.12 | 2.43 ± 1.18 | 0.072 |
| DV | − 0.89 ± 1.93 | − 0.79 ± 1.31 | 0.704 |
| HOMA-β | |||
| Before | 27.75 ± 16.03 | 24.08 ± 17.32 | 0.405 |
| After | 68.62 ± 45.21 | 49.21 ± 24.36 | 0.037* |
| DV | 40.87 ± 23.52 | 25.13 ± 19.21 | 0.006* |
| HbA1c (%) | |||
| Before | 9.79 ± 1.86 | 9.15 ± 2.26 | 0.246# |
| After | 7.00 ± 0.84 | 7.01 ± 1.05 | 0.968 |
| DV | − 2.79 ± 1.53 | − 2.14 ± 1.74 | 0.137 |
| TG (mmol/L) | |||
| Before | 2.46 ± 1.96 | 2.31 ± 1.90 | 0.766 |
| After | 2.21 ± 1.91 | 1.79 ± 1.23 | 0.306 |
| DV | − 0.25 ± 1.95 | − 0.52 ± 1.58 | 0.096# |
| TC (mmol/L) | |||
| Before | 5.27 ± 1.69 | 5.22 ± 1.15 | 0.892# |
| After | 4.84 ± 1.12 | 4.89 ± 1.37 | 0.880# |
| DV | − 0.43 ± 1.53 | − 0.33 ± 1.09 | 0.769# |
| HDL-c (mmol/L) | |||
| Before | 1.42 ± 0.51 | 1.47 ± 0.47 | 0.695# |
| After | 1.35 ± 0.55 | 1.43 ± 0.51 | 0.563# |
| DV | − 0.07 ± 0.68 | − 0.04 ± 0.46 | 0.839 |
| LDL-c (mmol/L) | |||
| Before | 3.28 ± 1.19 | 3.18 ± 1.05 | 0.731# |
| After | 3.19 ± 1.20 | 3.11 ± 1.07 | 0.786 |
| DV | − 0.09 ± 1.26 | − 0.07 ± 1.08 | 0.948 |
BMI body mass index, WHR waist to hip ratio, FPG fasting plasma glucose, PPG postprandial plasma glucose, FINS fasting serum insulin, PINS postprandial serum insulin, HOMA-IR homeostasis model assessment for insulin resistance, HOMA-β Homeostasis model assessment for islet β cell function, HbA1c hemoglobin A1c, TG triglyceride, TC total cholesterol, HDL-c high-density lipoprotein-cholesterol, LDL-c low-density lipoprotein-cholesterol, DV differential values (post-administration minus pre-administration)
Data are given as (mean ± SD). ΔP values are determined by the Pearson chi-square test. #P values are determined by the Kruskal–Wallis test. *P < 0.05