Fig. 3.

Rutin rescues memory deficits in Tau-P301S mice. A Schematic representation of pharmacological treatment and experimental measurement. B–D The Morris water maze was performed on Tau-P301S mice and their WT littermates treated with rutin or vehicle. (n = 8 mice). B The latency to find the hidden platform was measured during training trials. C, D During probe trials, the latency to the position of the removed platform (C) and the number of platform crossings (D) were measured. E The time spent in the novel arm in Y-maze test was determined on Tau-P301S mice and their WT littermates treated with rutin or vehicle (n = 8 mice). F The novel object recognition test was performed on Tau-P301S mice and their WT littermates treated with rutin or vehicle. The results were expressed as the discrimination index (n = 8 mice). Data represent means ± SEM and were analyzed by two-way ANOVA with Bonferroni’s test (B) or one-way ANOVA with Tukey’s test (C–F). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, not significant