Fig. 6.

Rutin rescues synapse loss in Tau-P301S mice. A PSD95 immunostaining and synaptophysin immunostaining in the brains of Tau-P301S mice and their WT littermates treated with rutin or vehicle (scale bar: 3 μm). B–D Quantification of PSD95 puncta (B), synaptophysin puncta (C) and their apposition (D) in A. (n = 8 mice). Data represent means ± SEM and were analyzed by one-way ANOVA with Tukey’s test (B–D). **P < 0.01, ****P < 0.0001, ns, not significant