Fig. 7.

Rutin prevents microglial synapse engulfment in Tau-P301S mice. A Representative images show the engulfed PSD95 (red) puncta within Iba-1⁺ (green) microglial cells in the brains of Tau-P301S mice and their WT littermates treated with rutin or vehicle (scale bar: white, 10 μm; cyan, 5 μm; red, 5 μm). B Quantification of PSD95 puncta per Iba-1⁺ microglial cell (n = 8 mice). Data represent means ± SEM and were analyzed by one-way ANOVA with Tukey’s test. ****P < 0.0001, ns, not significant