Table 7.
Top 40 GO Biological Processes associated to POAG and with target miRNAs.
| ID | Name | N | p-Value | ID | Name | N | p-Value | ||
|---|---|---|---|---|---|---|---|---|---|
| 1 | GO:0030198 | extracellular matrix organization | 31 | 4.63E-25 | 21 | GO:0016043 | cellular component organization | 75 | 1.88E-09 |
| 2 | GO:0043062 | extracellular structure organization | 31 | 5.15E-25 | 22 | GO:0008219 | cell death | 40 | 1.89E-09 |
| 3 | GO:0009653 | anatomical structure morphogenesis | 51 | 2.36E-15 | 23 | GO:0071840 | cellular component organization or biogenesis | 76 | 2.58E-09 |
| 4 | GO:0150063 | visual system development | 19 | 7.78E-15 | 24 | GO:0048592 | eye morphogenesis | 11 | 3.22E-09 |
| 5 | GO:0048880 | sensory system development | 19 | 1.36E-14 | 25 | GO:0042981 | regulation of apoptosis | 33 | 3.92E-09 |
| 6 | GO:0001654 | eye development | 18 | 1.20E-13 | 26 | GO:0012501 | programmed cell death | 38 | 5.16E-09 |
| 7 | GO:0048513 | animal organ development | 52 | 1.29E-13 | 27 | GO:0090596 | sensory organ morphogenesis | 12 | 7.97E-09 |
| 8 | GO:0009887 | animal organ morphogenesis | 29 | 2.37E-13 | 28 | GO:0009888 | tissue development | 35 | 1.41E-08 |
| 9 | GO:0007423 | sensory organ development | 19 | 1.27E-12 | 29 | GO:0050793 | regulation of development | 42 | 2.22E-08 |
| 10 | GO:0007275 | multicellular organism development | 65 | 3.25E-12 | 30 | GO:0072359 | circulatory system development | 26 | 4.96E-08 |
| 11 | GO:0048731 | system development | 61 | 3.20E-11 | 31 | GO:0007166 | cell surface receptor signaling pathway | 48 | 7.24E-08 |
| 12 | GO:0030199 | collagen fibril organization | 10 | 1.50E-10 | 32 | GO:0042073 | intraciliary transport | 9 | 8.63E-08 |
| 13 | GO:0048646 | morphogenesis | 29 | 1.74E-10 | 33 | GO:0097190 | apoptotic signaling pathway | 20 | 1.02E-07 |
| 14 | GO:0032502 | development | 70 | 3.01E-10 | 34 | GO:0032501 | multicellular organismal process | 73 | 1.22E-07 |
| 15 | GO:0010941 | regulation of cell death | 36 | 4.22E-10 | 35 | GO:0007601 | visual perception | 12 | 1.78E-07 |
| 16 | GO:0043010 | anterior chamber eye development | 14 | 4.33E-10 | 36 | GO:0010970 | transport along microtubule | 12 | 1.95E-07 |
| 17 | GO:0048856 | anatomical structure development | 66 | 5.22E-10 | 37 | GO:0050953 | sensory perception of light stimulus | 12 | 3.29E-07 |
| 18 | GO:0006915 | Apoptosis | 37 | 1.24E-09 | 38 | GO:0032963 | collagen metabolic process | 10 | 3.95E-07 |
| 19 | GO:0043067 | Apoptosis regulation | 34 | 1.33E-09 | 39 | GO:0035735 | intraciliary transport involved in cilium assembly | 8 | 4.31E-07 |
| 20 | GO:0006928 | movement of cell or subcellular component | 42 | 1.75E-09 | 40 | GO:0098840 | protein transport along microtubule | 9 | 4.81E-07 |
GO: Gene Ontology; POAG: primary open-angle glaucoma; N: number of genes.