Table 8.
Reactomes associated with the 8 tear differentially expressed miRNAs.
| ID | Name | N | p-Value |
|---|---|---|---|
| REAC:R-HSA-1474244 | Extracellular matrix organization | 29 | 5.16E-21 |
| REAC:R-HSA-1474228 | Extracellular matrix degradation | 18 | 2.59E-14 |
| REAC:R-HSA-1442490 | Collagen degradation | 13 | 1.48E-12 |
| REAC:R-HSA-3000178 | ECM proteoglycans | 13 | 1.33E-11 |
| REAC:R-HSA-3000171 | Non-integrin membrane-ECM interactions | 12 | 1.43E-11 |
| REAC:R-HSA-2022090 | Assembly of collagen fibrils (and other multimeric structures) | 12 | 2.21E-11 |
| REAC:R-HSA-8948216 | Collagen chain trimerization | 10 | 7.82E-10 |
| REAC:R-HSA-1474290 | Collagen formation | 12 | 3.08E-09 |
| REAC:R-HSA-2243919 | Crosslinking of collagen fibrils | 7 | 2.62E-08 |
| REAC:R-HSA-216083 | Integrin cell surface interactions | 11 | 3.35E-08 |
| REAC:R-HSA-8874081 | MET activates PTK2 signaling | 8 | 3.46E-08 |
| REAC:R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 10 | 6.68E-08 |
| REAC:R-HSA-8875878 | MET promotes cell motility | 8 | 4.25E-07 |
| REAC:R-HSA-1566948 | Elastic fiber formation | 8 | 9.52E-07 |
| REAC:R-HSA-5620924 | Intraflagellar transport | 8 | 5.22087E-06 |
| REAC:R-HSA-2129379 | Molecules associated with elastic fibers | 7 | 7.44538E-06 |
| REAC:R-HSA-109581 | Apoptosis | 12 | 8.49652E-06 |
| REAC:R-HSA-5357801 | Apoptosis regulation | 12 | 1.0277E-05 |
| REAC:R-HSA-3000170 | Syndecan interactions | 6 | 2.27603E-05 |
| REAC:R-HSA-2214320 | Anchoring fibril formation | 5 | 4.00759E-05 |
| REAC:R-HSA-6806834 | Signaling by MET | 8 | 8.14274E-05 |
| REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | 7 | 9.9991E-05 |
| REAC:R-HSA-375165 | NCAM signaling for neurite out-growth | 7 | 2.12464E-04 |
| REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 16 | 3.8436E-04 |
| REAC:R-HSA-419037 | NCAM1 interactions | 6 | 4.6565E-04 |
| REAC:R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8 | 1.40305E-03 |
| REAC:R-HSA-186797 | Signaling by PDGF | 6 | 2.114864E-03 |
| REAC:R-HSA-5617833 | Cilium Assembly | 10 | 2.548397E-03 |
| REAC:R-HSA-381426 | IGF transport & uptake by IGF Binding Proteins (IGFBPs) | 8 | 3.42679E-03 |
| REAC:R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5 | 5.752906E-03 |
| REAC:R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5 | 1.1963399E-02 |
| REAC:R-HSA-76002 | Platelet activation, signaling and aggregation | 10 | 2.1334022E-02 |
| REAC:R-HSA-3000157 | Laminin interactions | 4 | 4.1196772E-02 |
| REAC:R-HSA-114452 | Activation of BH3-only proteins | 4 | 4.1196772E-02 |
| REAC:R-HSA-6803207 | TP53 regulation of Caspase activator/Caspases Transcription | 3 | 4.5562937E-02 |
N: number of genes; REAC: reactome.