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. 2021 May 21;22(11):5416. doi: 10.3390/ijms22115416

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Distributions of the Relative Solvent Accessibility (RSA) and frequency of the wild-type residue (f_wt) in the multiple sequences of homolog proteins. The distributions of RSA and f_wt calculated for the subsets of 53 highly destabilizing variants (ΔΔG_f > 2.0 kcal/mol) compared to the remaining 111 variants (ΔΔG_f ≤ 2.0 kcal/mol) are shown in panels (a,c). In panels (b,d) the same distributions are plotted for the subsets of 24 putative cancer-driving (Tier 1–3) or 73 benign (‘Other’) variants.