Table 1.
Baseline clinico-pathological characteristics of patients and correlation with response to ICB.
| Characteristics | Total (n = 69) |
CB (n = 33) |
PD (n = 36) |
p-Value |
|---|---|---|---|---|
| Age | 0.276 | |||
| ≤66 | 34 (49.3%) | 14 (42.4%) | 20 (55.6%) | |
| >66 | 35 (50.7%) | 19 (57.6%) | 16 (44.4%) | |
| Gender | 0.015 | |||
| Male | 49 (71.0%) | 28 (84.8%) | 21 (58.3%) | |
| Female | 20 (29.0%) | 5 (15.2%) | 15 (41.7%) | |
| Smoking status | 0.805 | |||
| Smoker | 47 (68.1%) | 22 (66.7%) | 25 (69.4%) | |
| Non-smoker | 22 (31.9%) | 11 (33.3%) | 11 (30.6%) | |
| Body mass index | 0.035 | |||
| High (≥25) | 32 (46.4%) | 20 (60.6%) | 12 (33.3%) | |
| Low (<25) | 33 (47.8%) | 12 (36.4%) | 21 (58.3%) | |
| Non-specified | 4 (5.8%) | 1 (3.0%) | 3 (8.4%) | |
| Antibiotics previous | 0.710 | |||
| Yes | 16 (23.2%) | 7 (21.2%) | 9 (25.0%) | |
| No | 53 (76.8%) | 26 (78.8%) | 27 (75.0%) | |
| ECOG performance status | 0.110 | |||
| 0–1 | 63 (91.3%) | 32 (97.0%) | 31 (86.1%) | |
| ≥2 | 6 (8.7%) | 1 (3.0%) | 5 (13.9%) | |
| Stage | 0.151 | |||
| III | 12 (17.4%) | 8 (24.2%) | 4 (11.1%) | |
| IV | 57 (82.6%) | 25 (75.8%) | 32 (88.9%) | |
| Histology | 0.528 | |||
| Adenocarcinoma | 32 (46.4%) | 14 (42.4%) | 18 (50.0%) | |
| Non-adenocarcinoma | 37 (53.6%) | 19 (57.6%) | 18 (50.0%) | |
| PD-L1 | 0.034 | |||
| Positive (TPS ≥ 1%) | 46 (66.7%) | 26 (78.8%) | 20 (55.6%) | |
| Negative (TPS < 1%) | 21 (30.4%) | 6 (18.2%) | 15 (41.7%) | |
| Non-specified | 2 (2.9%) | 1 (3.0%) | 1 (2.8%) | |
| Immunotherapy | 0.265 | |||
| 1st line | 37 (53.6%) | 20 (60.6%) | 17 (47.2%) | |
| Non-1st line | 32 (46.4%) | 13 (39.4%) | 19 (52.8%) | |
| Tumor size | 0.180 | |||
| ≤5 cm | 16 (23.2%) | 10 (30.3%) | 6 (16.7%) | |
| >5 cm | 53 (76.8%) | 23 (69.7%) | 30 (83.3%) | |
| Number of metastatic sites | 0.127 | |||
| <2 | 27 (39.1%) | 16 (48.5%) | 11 (30.6%) | |
| ≥2 | 42 (60.9%) | 17 (51.5%) | 25 (69.4%) |
Non-smoker: never smoker + former smoker; ECOG: Eastern cooperative oncology group; TPS: tumor proportion score. p-values were obtained using the chi-square test. Bold p-values denote statistical significance at the p < 0.05 level.