Table 1.
KDEL receptor expression is altered in disease states. Arrows indicate changes in gene expression.
| Model | KDELR1 | KDELR2 | KDELR3 | Reference |
|---|---|---|---|---|
| Ischemia | ||||
| Cerebral ischemic stroke RNAseq | ↑ | ↑ | ↑ | [52] |
| Myocardial infarction RNAseq | ↑ | ↑ | [53] | |
| Myocardial infarction with ischemic postconditioning RNAseq | ↓ | ↓ | [53] | |
| SH-SY5Y oxygen–glucose deprivation RT-qPCR | ↑ | [8] | ||
| Ischemic cardiomyopathy RNAseq | ↑ | [54] | ||
| Cancer | ||||
| Colorectal carcinoma CDNA microarray | ↑ | [56] | ||
| YCC-16 gastric cancer cell line cDNA microarray | ↓ | [57] | ||
| Glioma tissue TCGA, CGGA and GSE16011 database | ↑ | [58] | ||
| Melanoma human tumor RNAseq | ↑ | [59] | ||
| FMPC optic glioma RNAseq | ↑ | [60] | ||
| Glioblastoma tissue qRT-PCR | ↑ | [61] | ||
| Pancreatic Disorders | ||||
| Pancreatic islets modified by palmitate RNAseq | ↓ | [62] | ||
| Type 2 Diabetes GeneChip expression array | ↑ | ↑ | [63] | |
| Type 2 Diabetes db/db mice RNAseq | ↑ | [64] | ||
| Diabetic glomeruli and tubulointerstitium RNAseq | ↑ | ↑ | [65] | |
| Heart Disease | ||||
| Dilated cardiomyopathy RNAseq | ↓ | [54] | ||
| Heart failure RNAseq | ↓ | ↑ | [66] | |
| Dilated cardiomyopathy RNAseq | ↑ | [67] | ||
| Other | ||||
| Liver regeneration following partial hepatectomy RNAseq | ↑ | [68] | ||
| Liver regeneration following portal vein ligation RNAseq | ↑ | [68] | ||
| Liver regeneration following associated liver partition and portal vein ligation for staged hepatectomy RNAseq | ↑ | [68] | ||
| Chronic obstructive pulmonary disease RNAseq | ↑ | [69] | ||
| Irritable bowel syndrome rectal biopsy qPCR | ↑ | [70] | ||
| Subclinical acute rejection of kidney transplant RNAseq | ↓ | [71] |