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. 2021 May 21;13(11):2534. doi: 10.3390/cancers13112534

Table 3.

Relevant compounds from the meta-analysis results considering only the vote-counting results. The compounds shown are found in at least two different cohorts. Compounds in bold have a vote count of at least 2 for the upregulated compounds and −2 for the downregulated compounds.

Common Name No. of Cohorts Behavior
(Up-Down-Equal)
Vote-Counting N Reference
CRC and Advanced Adenoma vs. Control
N1,N12-Diacetylspermine 3 3–0–0 3 928 [24,25] ɫ
D-Glucose 2 2–0–0 2 696 [24] ɫ
L-Kynurenine 2 2–0–0 2 696 [24] ɫ
L-Proline 2 2–0–0 2 696 [24] ɫ
Creatinine 2 0–2–0 −2 452 [35,36]
Phenol 2 0–2–0 −2 294 [29,35]
Putrescine 3 2–0–1 2 900 [24,35] ɫ
Hippuric acid 4 0–3–1 −3 1148 [24,35,36] ɫ
Indole-3-acetic acid 3 0–2–1 −2 900 [24,35] ɫ
Citric acid 5 1–3–1 −2 1271 [24,35,36,43] ɫ
P-Cresol 2 1–1–0 1 417 [35,43]
Tetradecenoyl carnitine (C14:1) 2 1–0–1 1 696 [24] ɫ
2-Aminohexanedioic acid 2 0–1–1 −1 696 [24] ɫ
3-(3-Hydroxyohenyl)-3-hydroxypropanoic acid 2 0–1–1 −1 696 [24] ɫ
Aspartic acid 2 0–1–1 −1 696 [24] ɫ
3-Hidroxybutyric acid 2 1–1–0 0 696 [24] ɫ
Butyric acid 2 1–1–0 0 696 [24] ɫ
Hydroxyproline 2 1–1–0 0 696 [24] ɫ
L-Alanine 2 1–1–0 0 452 [35,36]
L-Dopa 2 1–1–0 0 696 [24] ɫ
L-Tryptophan 2 1–1–0 0 327 [35,43]
Urea 2 1–1–0 0 452 [35,36]
CRC Stage vs. Control
Hippuric acid 2 1–1–0 0 248 [37,44]
Pre-surgery vs. Post-surgery
Salicyluric acid 2 0–2–0 −2 258 [43,44]
Asparagine 2 1–1–0 0 258 [43,44]
Citrate 2 1–1–0 0 258 [43,44]
Tyrosine 2 1–1–0 0 246 [43,44]

ɫ Reference [24] has two cohorts for this is included twice.