Table 4.
Meta-analysis results for the significant compounds in colorectal cancer and advanced adenoma vs. control comparison, including the healthy normal urine concentrations (extracted from the human metabolome database) and the projected colorectal cancer concentrations in urine. NQ: not quantified in urine.
| Compound Name | Combined and Weighted p-Value | Combined and Weighted Fold-Change | N Total | HMDB ID | Healthy Normal Urine Concentration (Adult > 18 y) (µmol/mmol Creatinine) | CRC Projected Urine Concentration (Adult > 18 y) (µmol/mmol Creatinine) |
|---|---|---|---|---|---|---|
| 3-Hidroxybutyric acid | 1.85 × 10−4 | 17.56 | 342 | HMDB0000357 | 1.4–2.7 | 5.8–11.2 |
| L-Dopa | 2.60 × 10−4 | 14.63 | 342 | HMDB0000181 | 0.01–0.04 | 0.04–0.15 |
| L-Histidinol | 8.71 × 10−9 | 12.76 | 204 | HMDB0003431 | NQ | - |
| N1,N12-Diacetylspermine | 6.00 × 10−14 | 10.75 | 342 | HMDB0002172 | 0–0.0260 | 0–0.280 |
| 1,1,6-Trimethyl-1,2-dihydronaphthalene | 3.31 × 10−2 | 0.22 | 60 | HMDB0040284 | NQ | - |
| Hippuric acid | 2.59 × 10−3 | 0.23 | 546 | HMDB0000714 | 28–610 | 6–140 |
| Ether | 1.42 × 10−3 | 0.18 | 60 | - | NQ | - |
| Pyruvic acid | 8.82 × 10−8 | 0.09 | 204 | HMDB0000243 | 1–3.7 | 0.09–0.33 |
| Butyraldehyde | 5.76 × 10−4 | 0.003 | 60 | HMDB0003543 | NQ | - |