Figure 3.

Pathway analysis of differential proteins in BC NAF. (a) Reactome pathway analysis of differential expressed proteins of BC NAF. Significantly enriched pathways included the innate immune system (blue), metabolism of proteins (orange), hemostasis (yellow) and ECM organization (green) (p ≤ 0.05). Each pathway is labelled with the number of significantly differentiated proteins involved in the listed pathway; the STRING protein database was used to analyze the protein–protein interactions of significantly differentiated protein associated with (b) the immune system pathways; (c) ECM-associated proteins; (d) hemostatic proteins; (e) proteins associated with the IGF pathway; colored lines between the nodes (proteins) indicate the various types of interaction evidence in the STRING protein database.