Table 1.
Clinical parameters of NC (n = 4) and BC (n = 9) subjects selected for NAF LC-MS/MS analysis.
| Subject | Pathology | Disease Breast | Grade | TNM Staging | Phenotype | Age | Pre/Post-Menopausal | Breast | NAF—Appearance | Conc. mg/mL | Total Protein (μg) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NC1 | Normal | N/A | N/A | N/A | N/A | 48 | Pre | Left | White, cloudy | 15.86 | 793.00 |
| Right | White, cloudy | 18.20 | 910.00 | ||||||||
| NC2 | Normal | N/A | N/A | N/A | N/A | 31 | Pre | Left | Light brown-waxy | 34.72 | 4999.49 |
| Right | Light brown-waxy | 33.30 | 4961.17 | ||||||||
| NC3 | Benign (phyllodes) | Right | N/A | N/A | N/A | 43 | Pre | Left | White, cloudy | 16.53 | 793.00 |
| Right | Light brown, cloudy | 21.50 | 1892.00 | ||||||||
| NC4 | Benign (duct ectasia) | Left | N/A | N/A | N/A | 59 | Post | Left | Terracotta, thick | 65.81 | 7831.75 |
| Right | Light brown, thick | 81.20 | 8039.20 | ||||||||
| BC1 | DCIS | Left | N/A | N/A | N/A | 62 | Post | Left | Yellow, cloudy | 26.80 | 750.00 |
| Right | Yellow, cloudy | 27.52 | 770.00 | ||||||||
| BC2 | DCIS | Right | N/A | N/A | N/A | 57 | Post | Left | Light brown, cloudy | 63.25 | 1138.46 |
| Right | Light brown, cloudy | 28.04 | 504.79 | ||||||||
| BC3 | IC (ductal) | Left | 1 | G1 T3 N? | ER+ve/HER2−ve | 59 | Post | Left | White, cloudy | 3.28 | 522.00 |
| Right | Olive green, thick | 15.82 | 1725.00 | ||||||||
| BC4 | IC (ductal) | Right | 3 | G3 pT2 pN0 | ER+ve/HER2−ve | 50 | Post | Left | Light brown, cloudy | 35.14 | 1687.00 |
| Right | Light brown, cloudy | 22.74 | 637.00 | ||||||||
| BC5 | IC (ductal) | Right | 3 | G3 T1c or T2 N0? | ER+ve/HER2−ve | 86 | Post | Left | Light brown, cloudy | 58.81 | 11,643.43 |
| Right | Light brown, cloudy | 69.48 | 8893.00 | ||||||||
| BC6 | IC (ductal) | Right | 1 | pT2 | ND | 48 | Pre | Left | White, cloudy | 14.65 | 1743.25 |
| Right | Light brown, cloudy | 42.30 | 3342.02 | ||||||||
| BC7 | IC (ductal) | Right | ND | pT1c N1 | ND | 47 | Pre | Left | Yellow, translucent | 35.46 | 921.96 |
| Right | Red, opaque | 53.80 | 699.40 | ||||||||
| BC8 | IC (ductal) | Right | 1 | G1 ypT1c ypN2 | Tubular | 44 | Pre | Left | White, opaque | 39.72 | 993.00 |
| Right | White, opaque | 22.13 | 774.55 | ||||||||
| BC9 | IC (ductal) | Left | 2 | G2 pT1c | NST | 47 | ND | Left | Yellow-brown, thick | 46.91 | 3471.64 |
| Right | Yellow-brown, thick | 62.97 | 7493.91 |
NC—non-cancer, BC—breast cancer, DCIS—ductal carcinoma in situ, IC—invasive carcinoma, N/A—Not applicable, G—Grade (1–3), T—Tumor status, N—Lymph node status, p—pathological stage, ?—Undefined, ER—Estrogen receptor status, HER2—Human epidermal growth factor receptor 2 status, +ve—Positive, −ve—Negative, ND—Not disclosed.