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. 2021 May 21;22(11):5443. doi: 10.3390/ijms22115443

Figure 7.

Figure 7

A33 does not affect motor coordination or the sedative–hypnotic properties of alcohol in A33/alcohol-experienced mice. Summary of the effects of pretreatment with either vehicle (VEH) or 1.0 mg/kg of A33 (1.0 A33) on (A) the latency of female and male B6NJ mice (8 females/7 males) to fall from a rotarod under an alcohol-free (Base; 30 min pretreatment) and alcohol-intoxicated state (3 mg/kg EtOH; ~75 min pretreatment). (B) Same as Panel A for female and male B6J mice (12 females/11 males). (C) Summary of the effects of VEH or A33 upon the time taken by B6NJ mice to regain their righting reflex following injection with 4 g/kg of alcohol. (D) Same as Panel C for B6J mice. The data represent the mean ± SEM of the aforementioned number of mice, in addition to the individual data points for each experimental group.