Figure 10.

Repeated, intermittent treatment with 1.0 mg/kg A33 reduces alcohol intake under single-bottle DID procedures. (A) Comparison of the effects of acute pretreatment (30 min prior) with 1.0 mg/kg of A33 (1.0 A33) upon the intake of 20% alcohol under DID procedures between B6NJ and B6J mice. (B) Summary of the effect of repeated, intermittent, pretreatment with 1.0 mg/kg of A33 upon the intake of 20% alcohol by all of the mice in Experiment 2. Note that the data are expressed as a percentage of the average baseline alcohol intake, depicted in Panel A. Comparison of the baseline intake of 20% alcohol prior to A33 treatment (B) and the alcohol intake observed on the days between A33 injections in (C) B6NJ and (D) B6J mice. Comparison of the alcohol intake exhibited by female and male B6NJ and B6J mice on the final drinking day prior to blood collection (E) and their resultant BECs (F). The data represent the mean ± SEM of the number of mice indicated, in addition to the individual data points for each experimental group. * p < 0.05 vs. Baseline (main effect); + vs. Females (main effect).