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. 2021 May 21;22(11):5432. doi: 10.3390/ijms22115432

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Venn diagram showing mRNAs that bind to METTL8 via a putative target gene list of METTL8(11), a tumor suppressor genes list (18), and a list of cancer migration-related genes. (B) Schematic summary of the RIP protocol followed by RT-qPCR were created in BioRender.com. (C) Western blot shows the expression of Flag-tagged METTL8 protein in the RIP lysate. (D) RT-qPCR detection of positive control U1 snRNA in RNAs enriched by anti-snRNP70 RIP. ** indicates p < 0.01. (E) ARID1A mRNA was highly enriched in the RNAs enriched by anti-Flag METTL8 RIP by RT-qPCR. MDA-MB-231 cells were subjected to RIP assay after transfection with Flag-tagged METTL8 cDNA ORF Clone. ** indicates p < 0.01.