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. 2021 May 22;22(11):5467. doi: 10.3390/ijms22115467

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cell growth inhibition by methylselenol (MeSeH) precursors. Exponentially growing BY4741 cells in SC medium supplemented with 100 µM methionine were diluted to 0.1 OD₆₀₀ in the same medium and left to grow for 2 h. At time zero, 0 (), 25 () or 100 µM () of methylselenoglutathione (MeSeSG) (left panel) or dimethyldiselenide (DMDSe) (right panel) were added and cell growth was monitored by measuring the OD₆₀₀ at various times during 6 h. Data were plotted on a semi-log scale as a function of time. Doubling times of 119 ± 14 (control), 147 ± 16 (25 µM MeSeSG), 192 ± 19 (100 µM MeSeSG), 157 ± 16 (25 µM DMDSe) and 223 ± 24 (100 µM DMDSe) min were calculated by using regression analysis. The results are the mean and range of two experiments.

Inline graphic — Cell growth inhibition by methylselenol (MeSeH) precursors. Exponentially growing BY4741 cells in SC medium supplemented with 100 µM methionine were diluted to 0.1 OD₆₀₀ in the same medium and left to grow for 2 h. At time zero, 0 (), 25 () or 100 µM () of methylselenoglutathione (MeSeSG) (left panel) or dimethyldiselenide (DMDSe) (right panel) were added and cell growth was monitored by measuring the OD₆₀₀ at various times during 6 h. Data were plotted on a semi-log scale as a function of time. Doubling times of 119 ± 14 (control), 147 ± 16 (25 µM MeSeSG), 192 ± 19 (100 µM MeSeSG), 157 ± 16 (25 µM DMDSe) and 223 ± 24 (100 µM DMDSe) min were calculated by using regression analysis. The results are the mean and range of two experiments.