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. 2021 May 21;13(11):2539. doi: 10.3390/cancers13112539

Figure 4.

Figure 4

Patient-derived organoid-based drug efficacy prediction and potential clinical impact. (A), Immunohistochemistry staining for GATA6 in patient-derived organoids (PDOs) 34 and 43 and corresponding tumor tissue from liver metastases. (B), Distribution of classical (green) and basal-like (yellow) subtypes across PDOs and corresponding tumor tissues. (C), Kaplan-Meier analysis of progression-free survival (PFS) of treatment-naïve advanced pancreatic cancer (PC) patients according to their classical or basal-like subtype status. (D), Immunohistochemistry staining for Ki-67 in PDOs 34 and 49 and corresponding tumor tissue. A tumor cell Ki-67 positivity ≤ 45% shows low proliferation, while Ki-67 >45% denotes high proliferation. (E), Contingency table showing proliferation index and sensitivity to chemotherapy regimen in vitro. (F), Kaplan-Meier analysis of PFS of treatment-naïve advanced PC patients according to the tumor mitotic index. (G) Kaplan-Meier analysis of PFS of treatment-naïve advanced PC patients who received a tumor sensitive or tumor resistant predicted regimen following our PDO-based model. (H) Swimmer plot of PFS from treatment-naïve patients. Scale bars represent 100 µm. PDO, patient-derived organoids; FOLFIRINOX, 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin; Gem/nab-p, gemcitabine, and nanoparticle albumin-bound paclitaxel; res, resistant; sen, sensitive.